If anything, I would like to see a spinoff involving D.W. and her friends/classmates. The series already feels kind of divided between Arthur and his friends and D.W. and her friends. Splitting into two separate series would be the most sensible way to go, I'd think. The D.W. series could be geared towards the preschool-age viewers while the Arthur series will still be for the tween-and-older crowd.
...I'm getting way off subject here, so I'll stop.
Half of us know somebody who would just absolutely blow his brains out if a spin-off was made based off the episode "In My Africa".