I've noticed that in many of the episodes, Francine's head, when seen from the side, sort of has a funny angle. Take a look at the first picture posted in this topic and notice how her nose seems a little roundly-shaped and kind of big.
Anyway, aside from the limited movement of the characters and the Flash animation. I really don't like the coloring. Everything looks like it was outlined with a big black Sharpie, and virtually EVERYTHING has no shading or variation in color. Snowth Woogle was right, it seems almost reminiscent of a computer game, but I think it reminds me more of those Flash games featured on the website.
Unfortunately, this is where the technology hype tends to lead us. We get so caught up in the idea that everything has to be animated with Flash or 3D that it often ends up looking worse, not better, than traditional animation. Call me a stickler for traditional ways if you will, as well as the rest of those who've grown up with the show since seasons 1-3, but that's just how I remember the show. The new animation is so distracting and different that it just isn't the same old Arthur I knew anymore.