Ive always had a pretty assertive idea of who should end up with who, because after awhile I get so frustrated with trying to pair everyone, that I usually conclude that a BusterxPizza would have to work. 
I think it should be:

ArthurxSue Ellen
(i mean, the recent bullying episode is not helping, but looking back...)
FrancinexGeorge
(for all people seem to think of George as a shy kid, he can be pretty boss. he and Francine would have a long road, but they would definitely end up together. wonder where this leaves Fern, though...)
BinkyxDW
(I'm guessing you saw that one coming.  )
MuffyxAlberto
(yes, the Molina one. think about it, it would probably take a good long time to start, but when they got going...)